Su Metcalfe received her Bachelor of Arts in Asian Studies from Pomona College in 1996. Following this, she received a Masters of Science in Biology with a focus in Immunology from NYU in 1999 and completed a research fellowship at the National Institutes of Health. She earned a Masters of Public Health degree from Columbia University in 2001. In 2005, she graduated from the University of Vermont College of Medicine.

After her internship in internal medicine at Beth Israel Deaconess Medical Center in Boston, Massachusetts, Dr. Metcalfe completed her radiation oncology training at the University of Rochester Medical Center in 2010. During her residency, she received training in stereotactic radiosurgery, image-guided radiotherapy, and intensity modulated radiation therapy. She participated in clinical research utilizing these techniques, specifically in the treatment of metastatic disease. She also performed laboratory research investigating the role of radiation in inducing tumor-specific immunologic response. Dr. Metcalfe has earned awards for research and excellence in patient care. She joined Radiation Oncology Associates in 2010.